The continuous increase in life-expectancy and lengthening of disease trajectories cause profound upheaval at an individual and a societal level. Above age 65, the great majority of people suffer multiple morbidities and polypharmacy is the rule. Age is the most important single risk factor of manifold diseases such as diabetes, cancer and dementia, but it is too often ignored as the underlying causal mechanism and largely understudied. Within the project Data for good science we make an investment in interdisciplinary research combining the strengths of the Danish data repositories, the access to the manifold biological samples in the hospital archives, and innovative computational analysis.