The aim of this project is to advance the methods for synthesizing evidence from randomized trials on the safety of interventions by developing and exploring meta-analytical models for correlated rare events and network meta-analysis of adverse events. We will develop multivariate approaches that are expected to increase precision in the estimation of the treatment effects. Such an increase in precision is highly desirable in the area of safety where events are rare. The team at ISPM will include Georgia Salanti, Orestis Efthimiou, Matthias Egger and Sven Trelle.
