To do this, HTA organisations need data from real life settings, yet there is little guidance on how to generate real world data and integrate the data into drug development before launch. The challenge is to incorporate alternative data sources and study designs into the earlier stages of drug research and development.
A group of ISPM researchers (Matthias Egger, Sven Trelle, Sandro Gsteiger, Klea Panayidou and others) will lead one of four GetReal packages. The theme of this work package is the estimation of relative effectiveness of drug interventions in chronic diseases based on different sources of evidence and methods, and the generalizability and applicability of relative effectiveness estimates to different patient populations. The investigators will use network meta-analysis and mathematical modelling and apply them to concrete case studies in oncology, cardiology and neurology. ISPM will work with researchers based at the University of Ioannina, Utrecht, Groningen and Leicester, and with pharmaceutical companies. The GetReal consortium is led by Diederick Grobbee (Utrecht) and Chris Chinn (GlaxoSmithKline).
GETREAL factsheet: http://www.imi.europa.eu/content/getreal
GETREAL website: http://www.imi-getreal.eu/
About IMI
The Innovative Medicines Initiative (IMI) is the world’s largest public-private partnership in health. IMI is improving the environment for pharmaceutical innovation in Europe by engaging and supporting networks of industrial and academic experts in collaborative research projects. The European Union contributes €1 billion to the IMI research programme, and this is matched by in kind contributions worth at least another €1 billion from the member companies of the European Federation of Pharmaceutical Industries and Associations (EFPIA).
The Innovative Medicines Initiative currently supports 46 projects, many of which are already producing impressive results. The projects are all working to address the biggest challenges in drug development, with the goal of accelerating the development of safer and more effective treatments for patients